Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes

(2017) Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes. Journal of Asian Natural Products Research.

Full text not available from this repository.

Abstract

Oleuropein mediates most of the beneficial effects of olive products. This study examined the role of oxidative stress in the effects of oleuropein on lipid profile and blood glucose in rats with simultaneous renovascular hypertension and type 2 diabetes. Eight groups (n = 7�9 each) of male Sprague-Dawley rats including a control, a type 2 diabetic, a renovascular hypertensive, a sham, a simultaneously hypertensive diabetic receiving vehicle, and 3 simultaneously hypertensive-diabetic receiving 20, 40, or 60 mg/kg/day oleuropein were used. Four weeks after treatment, blood glucose, lipid profile, and biomarkers of oxidative stress were measured, and glucose tolerance test (GTT) was performed. Simultaneously hypertensive diabetic rats had significantly higher blood pressure, blood glucose, and serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride and malondialdehyde. They also had lower serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and impaired glucose tolerance. Oleuropein significantly reduced blood pressure, blood glucose, and serum total cholesterol, LDL-C, triglyceride and malondoaldehyde. It also increased serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and improved glucose tolerance. The findings show that the model is associated with impaired glucose tolerance, and adverse lipid profile. They also show that oleuropein, partly by an antioxidant mechanism, improves glucose tolerance and changed lipid profile favorably. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Keywords: antioxidant; biological marker; cholesterol; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; malonaldehyde; natural product; oleuropein; superoxide dismutase; triacylglycerol; antioxidant; glucose blood level; iridoid; lipid; malonaldehyde; oleuropein; streptozocin; superoxide dismutase, animal experiment; animal model; antioxidant activity; Article; blood pressure measurement; cholesterol blood level; controlled study; diabetes control; drug structure; enzyme blood level; erythrocyte count; glucose blood level; glucose tolerance; glucose tolerance test; impaired glucose tolerance; insulin blood level; lipid analysis; male; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; protein blood level; rat; renovascular hypertension; systolic blood pressure; triacylglycerol blood level; animal; chemical structure; chemistry; Diabetes Mellitus, Type 2; disease model; drug effects; experimental diabetes mellitus; Hypertension, Renal; metabolism; renovascular hypertension; Sprague Dawley rat, Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose Tolerance Test; Hypertension, Renal; Hypertension, Renovascular; Iridoids; Lipids; Male; Malondialdehyde; Molecular Structure; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase
Subjects: pharmacology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology Pharmacology Medical
Depositing User: دکتر مهری غلامی
URI: http://eprints.abzums.ac.ir/id/eprint/2473

Actions (login required)

View Item View Item